Agr University of Athens classes I teach 2018-19
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Medical School of Athens classes I teach 2018-19
FINAL YEAR PROJECTS
Drug Design & Screening
In silico screening has always been and will be on the forefront of developments in the eminent field of drug design and medicinal chemistry. At the early days, drug discovery was based on blackboard drawings and expert intuition. However, as times move on, the amount of available information and overall knowledge base that needs to be analyzed cannot be processed manually. This, coupled by the rapid growth in computational infrastructure and processing power, has allowed for the efficient use of molecular docking tools and algorithms to be considered in the greater field of drug discovery. In the postgenomic era, molecular docking has become the key player for the screening of hundreds of thousands of compounds against a repertoire of pharmacological targets.
Following the completion of the Human Genome Project, new challenges emerged both by verifying its findings and by turning it into genomes from other organisms or by sub-questions about various diseases such as cancer. With cancer, unlike cardiovascular diseases or infections, mortality has remained steady over the last 50 years. Therefore, in the post-genomic era, the study of the molecular expression profile of genes has been gaining ground using advanced molecular techniques (such as DNA microarrays) and hypercompute bioinformatic analyses. Pharmacogenetics and pharmacogenomics are now the heart and soul of personalized and precision medicine. Gene expression profiling tests have entered clinical use and customized treatments are being designed based on the genomic profile of each cancer patient.
Systems Biology is a field that has been developed very recently but is finding more and more supporters and applications. The general idea concerns the interpretation of various biological events using systems theory. The concept of the system has been used for many years by many different sciences with a strong mathematical background. Thus, the introduction of such a concept in biology has given new impetus to the understanding of various structures and functions. From the study of individual biomolecules, systems biology has shifted its interest in the integrated study of biomolecules groups whose components interact synergistically for execution and integration biological functions, by integrating state of the art knowledge from such diverse fields in a comprehensive and easy to follow manner.